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KMID : 0376219750120030777
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Chonnam Medical Journal
1975 Volume.12 No. 3 p.777 ~ p.784
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Renal Function of the Heat-decorticated kidney Hemodynamic characteristics and electrolyte handling.
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Abstract
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In the study attempts were made to investigate the function of juxtamedullary nephron utilizing heat-decorticated kidney model which was recently introduced by Rashid et al.
Left kidney was immersed in water kept at 52˚C for 5 minutes. In 90% of cases the cortex of the kidney was necrotized as revealed at the time of experiment on 8th day. The right kidney underwent the same procedure except that the temperature of water was kept at 39˚ C, and served as control.
Hemodynamic characteristics and electrolyte handling of these kidneys were investigated and reported in this paper, Urine flow, glomerular filtration rate, and renal plasma flow in the decorticated kidney were 0.067 ±0.016, 0.87± 0.063, 2.61±0.290 xX/min., respectively, while those parameters in control kidney were 0.341±0.071, 5.10±0.148, 13.74 ±0.526 me/min. That is, those parameters in the decorticated kidney ranged only 1/5 to 1/6 of the control. Filtration fraction was not significantly different in both kidneys, suggesting that the ratio of the pre-and post-glomerular resistances in both kidneys was similar. No significant differences between inulin and creatinine clearances were found in the decorticated kidney.
Urinary sodium concentration and fractional excretion of sodium. was higher In the decorticated side, while the total excreted amount of sodium and sodium clearance were.lower.
Urinary potassium concentration was not different in both kidneys, but the fractional excretion of potassium was higher in the decorticated kidney, and the urinary K/Na ratio was lower in the decorticated kidney,
From these observations it is suggested that the hemodynamic characteritics are not different in both cortical and juxtarnedullar5 nephrons ijuxtamedullary nephron reabsorbs less sodium than -the-cortical nephron:
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